New molecular targets for cholesterol-lowering therapy.

  title={New molecular targets for cholesterol-lowering therapy.},
  author={N N Izzat and Mitchell Deshazer and David S Loose-Mitchell},
  journal={The Journal of pharmacology and experimental therapeutics},
  volume={293 2},
The use of 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitors (statins) in randomized clinical trials has established that cholesterol-lowering treatment reduces the risk of both cardiovascular and total mortality. This reduction in risk occurs in patients with or without existing cardiovascular disease and in patients with high or average plasma cholesterol concentrations. Aggressive treatment to lower plasma cholesterol has been shown to slow progression of atherosclerosis… CONTINUE READING
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