New models in cosmetics replacing animal testing

@article{Mone2014NewMI,
  title={New models in cosmetics replacing animal testing},
  author={Gregory Mone},
  journal={Communications of the ACM},
  year={2014},
  volume={57},
  pages={20 - 21}
}
  • Gregory Mone
  • Published 2014
  • Computer Science
  • Communications of the ACM
A European law spurs scientists to develop computational simulations capable of predicting the toxicity of cosmetics. 

Topics from this paper

Microfluidic platform for bilayer experimentation: from a research tool towards drug screening
Ion channels, which are located in the membranes of cells, are responsible for a number of physiological processes. Mutations in genes encoding ion channels resulting in alteration of their functionExpand
Computational model validation using a novel multiscale multidimensional spatio-temporal meta model checking approach
TLDR
A novel model checking approach which enables the efficient construction of reliable multiscale computational models of complex systems relative to how both numeric and spatial system properties are expected to change over time and across multiple scales is defined. Expand
Undergraduate programs in computational science
TLDR
The goal of this project is to provide an understanding of the wide range of computational assistance that is valuable to scientists, and to show that there is a tremendous variety of ways that an academic institution can provide training to students interested in a career related to computational science. Expand
The value of online surveys: a look back and a look ahead
TLDR
A detailed and critical look at the evolution of online survey research since Evans and Mathur’s (2005) article on the value of online surveys is presented. Expand

References

SHOWING 1-4 OF 4 REFERENCES
Quantitative Evaluation and Prediction of Drug Effects and Toxicological Risk Using Mechanistic Multiscale Models
TLDR
The required pieces, possibilities, and challenges in multiscale modeling for the prediction of drug effects are discussed, and the availability of validated cell‐type and organ‐specific kinetic metabolic models are considered. Expand
3D organotypic cultures of human HepaRG cells: a tool for in vitro toxicity studies.
TLDR
The results from this study suggest that the 3D organotypic HepaRG culture is a promising in vitro tool for more accurate assessment of acute and also possibly for chronic drug-induced hepatotoxicity. Expand
Prediction and validation of cell alignment along microvessels as order principle to restore tissue architecture in liver regeneration
TLDR
A procedure based on confocal laser scans, image processing, and three-dimensional tissue reconstruction, as well as quantitative mathematical modeling, which unambiguously predicted a so-far unrecognized mechanism as essential for liver regeneration, whereby daughter hepatocytes align along the orientation of the closest sinusoid, a process which is named “hepatocyte-sinusoid alignment” (HSA). Expand