New model of tumor angiogenesis: dynamic balance between vessel regression and growth mediated by angiopoietins and VEGF


Our analyses in several different tumor settings challenge the prevailing view that malignancies and metastases generally initiate as avascular masses that only belatedly induce vascular support. Instead, we find that malignant cells rapidly coopt existing host vessels to form an initially well-vascularized tumor mass. Paradoxically, the coopted vasculature… (More)
DOI: 10.1038/sj.onc.1203035


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