New model for crystalline polyglutamine assemblies and their connection with amyloid fibrils.

@article{Sikorski2005NewMF,
  title={New model for crystalline polyglutamine assemblies and their connection with amyloid fibrils.},
  author={Pawel Sikorski and Edward D T Atkins},
  journal={Biomacromolecules},
  year={2005},
  volume={6 1},
  pages={425-32}
}
Based on the interpretation of X-ray diffraction data reported for crystals of the poly-L-glutamine-rich 19-peptide D(2)Q(15)K(2), Perutz et al. (Proc. Natl. Acad. Sci. USA 2002, 99, 5591-5595) proposed that hollow, water-filled nanotubes are the basic structural motif of amyloid fibers. We are able to offer an alternative interpretation for the same X-ray diffraction data. Our proposed structure consists of beta-sheets, limited in size in the chain direction that stack at an intersheet… CONTINUE READING

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