New model for analysis of mucosal immunity: intestinal secretion of specific monoclonal immunoglobulin A from hybridoma tumors protects against Vibrio cholerae infection.

@article{Winner1991NewMF,
  title={New model for analysis of mucosal immunity: intestinal secretion of specific monoclonal immunoglobulin A from hybridoma tumors protects against Vibrio cholerae infection.},
  author={L S Winner and Judith A. Mack and Richard A Weltzin and John J Mekalanos and J. P. Kraehenbuhl and Marian R. Neutra},
  journal={Infection and immunity},
  year={1991},
  volume={59 3},
  pages={977-82}
}
Secretory immunoglobulin A (sIgA) plays a role in defense against Vibrio cholerae and other microorganisms that infect mucosal surfaces, but it is not established whether sIgA alone can prevent disease. We report here a strategy for identifying the antigen specificities of monoclonal sIgA antibodies that are capable of providing such protection. IgA hybridomas were generated from Peyer's patch lymphocytes after oral immunization with V. cholerae Ogawa 395. A clone was selected that produced… CONTINUE READING
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