New milbemycins from Streptomyces hygroscopicus subsp. aureolacrimosus: fermantation, isolation and strucutre elucidation.

@article{Nonaka2000NewMF,
  title={New milbemycins from Streptomyces hygroscopicus subsp. aureolacrimosus: fermantation, isolation and strucutre elucidation.},
  author={Kiyoko Nonaka and Takahiro Tsukiyama and Yasuko Okamoto and Kazuo Sato and C Kumasaka and T Yammoto and Fumito Maruyama and Hiromichi Yoshikawa},
  journal={The Journal of antibiotics},
  year={2000},
  volume={53 7},
  pages={694-704}
}
Twelve new milbemycins have been isolated and characterized from some strains derived from Streptomyces hygroscopicus subsp. aureolacrimosus SANK 60286 and SANK 60526. The metabolites 1 approximately 4 and 9 approximately 11 were produced by strain RM28D-688 SANK 60797 as minor products. The metabolites 5 approximaetly 8 were obtained from a broth of strain 57-338 SANK 61796. Strain MK-1391 SANK 62896 was used for the production of metabolite 12. The new metabolites, eight alpha-class and four… CONTINUE READING

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