New methylphenidate formulations for the treatment of attention-deficit/hyperactivity disorder

@article{Patrick2005NewMF,
  title={New methylphenidate formulations for the treatment of attention-deficit/hyperactivity disorder},
  author={Kennerly Sexton Patrick and Mario A. Gonz{\'a}lez and Arthur B. Straughn and John Seth Markowitz},
  journal={Expert Opinion on Drug Delivery},
  year={2005},
  volume={2},
  pages={121 - 143}
}
dl-Methylphenidate (MPH) remains the most widely used pharmacological agent in the treatment of attention-deficit/hyperactivity disorder (ADHD). The predominantly dopaminergic mechanism of the psychostimulant actions has become more clearly defined. Neuroimaging and genetic studies are revealing the underlying neuropathology in ADHD. Novel extended-release (ER) MPH formulations now offer drug delivery options to overcome both the short-term actions of immediate-release (IR) MPH and the acute… 

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TLDR
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TLDR
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TLDR
The various formulations of IR and intermediate- and extended-release methylphenidate and dexmethylphenidate can be useful options in satisfying patients' individual needs in the management of ADHD.

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TLDR
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TLDR
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Since there are no reliable biomarkers that can predict individualized response to long-acting stimulants, clinicians need to consider their distinctive pharmacokinetic properties, including the pharmacokinetics profile, rate and extent of absorption, variability, dose proportionality, bioequivalence and potential for accumulation.

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TLDR
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Differential pharmacokinetics and pharmacodynamics of methylphenidate enantiomers: does chirality matter?

TLDR
Data from in vitro, animal, and human studies support the premise that the d-enantiomer of MPH mediates the neurophysiological actions of MPH and therefore likely mediates its clinical efficacy.
...

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The psychostimulant dl‐methylphenidate (MPH) remains the most common drug therapy in child and adolescent psychiatry for the treatment of attention‐deficit‐hyperactivity disorder (ADHD). Evidence of

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TLDR
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TLDR
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TLDR
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TLDR
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TLDR
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TLDR
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TLDR
Comparisons of the two sets of plasma concentration curves suggest that MPH-SR has a longer Tmax, but that it does not reach the same Cmax as an identical dose of standard MPH.
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