New methods of structure refinement for macromolecular structure determination by NMR.

@article{Clore1998NewMO,
  title={New methods of structure refinement for macromolecular structure determination by NMR.},
  author={G. Clore and A. Gronenborn},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1998},
  volume={95 11},
  pages={
          5891-8
        }
}
  • G. Clore, A. Gronenborn
  • Published 1998
  • Medicine, Chemistry
  • Proceedings of the National Academy of Sciences of the United States of America
  • Recent advances in multidimensional NMR methodology have permitted solution structures of proteins in excess of 250 residues to be solved. In this paper, we discuss several methods of structure refinement that promise to increase the accuracy of macromolecular structures determined by NMR. These methods include the use of a conformational database potential and direct refinement against three-bond coupling constants, secondary 13C shifts, 1H shifts, T1/T2 ratios, and residual dipolar couplings… CONTINUE READING

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