New method of derivatization and headspace solid-phase microextraction for gas chromatographic-mass spectrometric analysis of amphetamines in hair.

@article{Liu2001NewMO,
  title={New method of derivatization and headspace solid-phase microextraction for gas chromatographic-mass spectrometric analysis of amphetamines in hair.},
  author={Juan Liu and Kenji Hara and Seiichi Kashimura and Masayuki Kashiwagi and Mitsuyoshi Kageura},
  journal={Journal of chromatography. B, Biomedical sciences and applications},
  year={2001},
  volume={758 1},
  pages={95-101}
}
A simple method for hair analysis of methamphetamine (MAMP) and amphetamine (AMP) by gas chromatography-mass spectrometry (GC-MS) was developed using simultaneous headspace solid-phase microextraction (HS-SPME) with derivatization. After alkaline-digestion of hair, the analytes derivatized with heptafluoro-n-butyryl chloride were adsorbed on a polydimethylsiloxane-coated fiber by HS-SPME and analyzed by GC-MS. Their mass spectra were, respectively, observable at 1 ng per sample. The standard… CONTINUE READING