New method for retrospective detection of exposure to organophosphorus anticholinesterases: application to alleged sarin victims of Japanese terrorists.

@article{Polhuijs1997NewMF,
  title={New method for retrospective detection of exposure to organophosphorus anticholinesterases: application to alleged sarin victims of Japanese terrorists.},
  author={Martine Polhuijs and Jan P. Langenberg and Hendrik P. Benschop},
  journal={Toxicology and applied pharmacology},
  year={1997},
  volume={146 1},
  pages={156-61}
}
With regard to detection of exposure to anticholinesterase, the presently used methods have the disadvantage that they cannot detect either low-level exposures with certainty or the structure of the agent and the extent of poisoning. In principle, organophosphate-inhibited butyrylcholinesterase in human plasma is the most persistent and abundant source for biomonitoring of exposure to organophosphate anticholinesterases. Fluoride ions reactivate the inhibited enzyme readily at pH 4, converting… CONTINUE READING

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