New method for detecting antiandrogenic effects through the measurement of external genitalia in rabbits

@article{Inawaka2010NewMF,
  title={New method for detecting antiandrogenic effects through the measurement of external genitalia in rabbits},
  author={Kunifumi Inawaka and Noriyuki Kishimoto and Hashihiro Higuchi and Takayuki Okamoto and Satoshi Kawamura},
  journal={Congenital Anomalies},
  year={2010},
  volume={50}
}
The aim of the present study was to develop a quantitative evaluation method for detecting antiandrogenic activity of chemicals in rabbits that are regularly used for developmental toxicity studies. Kbl: New Zealand White rabbits (n = 8–9) were injected intramuscularly with an antiandrogen, cyproterone acetate (CA; 10 mg/kg body weight [BW]/day), on gestation days (GD) 13–24. On GD 29, live fetuses were obtained by cesarean section and sexed by examination of the internal genitalia. The… 
1 Citations
Maternal exposure to procymidone has no effects on fetal external genitalia development in male rabbit fetuses in a modified developmental toxicity study.
TLDR
The results suggest that PCM has no effect on fetal external genitalia development in male rabbit fetuses, and species difference of developmental effects of PCM on sexual differentiation exists.

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