New method for bioavailability assessment of slow-release preparations of theophylline

Abstract

Variability in an individual's clearance of theophylline is an important consideration when estimating bioavailability. A method is described for compensating for this problem, using the serum concentration of theophylline and urinary excretion data on its major metabolites to make an estimation of the clearance after oral administration using the intravenous dose as reference. The method is particularly useful for assessing the bioavailability of slow-release theophylline preparations.

DOI: 10.1007/BF01058902

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Cite this paper

@article{Kasuya1985NewMF, title={New method for bioavailability assessment of slow-release preparations of theophylline}, author={Yasuji Kasuya and Tetsuro Ohno and Noriyoshi Kubota and Hidenori Takahashi and Hiroki Hirayama}, journal={Journal of Pharmacokinetics and Biopharmaceutics}, year={1985}, volume={13}, pages={571-587} }