New metabolically stabilized analogues of lysophosphatidic acid: agonists, antagonists and enzyme inhibitors.

@article{Prestwich2005NewMS,
  title={New metabolically stabilized analogues of lysophosphatidic acid: agonists, antagonists and enzyme inhibitors.},
  author={Glenn D. Prestwich and Yongqian Xu and Lian Qian and Joanna Gajewiak and Guowei Jiang},
  journal={Biochemical Society transactions},
  year={2005},
  volume={33 Pt 6},
  pages={1357-61}
}
Lysophosphatidic acid (LPA) is a metabolically labile natural phospholipid with a bewildering array of physiological effects. We describe herein a variety of long-lived receptor-specific agonists and antagonists for LPA receptors. Several LPA and PA (phosphatidic acid) analogues also inhibit LPP (lipid phosphate phosphatase). The sn-1 or sn-2 hydroxy groups have been replaced by fluorine, difluoromethyl, difluoroethyl, O-methyl or O-hydroxyethoxy groups to give non-migrating LPA analogues that… CONTINUE READING

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