New members of the mammalian glycerophosphodiester phosphodiesterase family: GDE4 and GDE7 produce lysophosphatidic acid by lysophospholipase D activity.

@article{Ohshima2015NewMO,
  title={New members of the mammalian glycerophosphodiester phosphodiesterase family: GDE4 and GDE7 produce lysophosphatidic acid by lysophospholipase D activity.},
  author={Noriyasu Ohshima and Takahiro Kudo and Y. Yamashita and Stefania Mariggi{\`o} and Mari Araki and Ayako Honda and Tomomi Nagano and Chiaki Isaji and Norihisa Kato and Daniela Corda and Takashi Izumi and Noriyuki Yanaka},
  journal={The Journal of biological chemistry},
  year={2015},
  volume={290 7},
  pages={4260-71}
}
The known mammalian glycerophosphodiester phosphodiesterases (GP-PDEs) hydrolyze glycerophosphodiesters. In this study, two novel members of the mammalian GP-PDE family, GDE4 and GDE7, were isolated, and the molecular basis of mammalian GP-PDEs was further explored. The GDE4 and GDE7 sequences are highly homologous and evolutionarily close. GDE4 is expressed in intestinal epithelial cells, spermatids, and macrophages, whereas GDE7 is particularly expressed in gastro-esophageal epithelial cells… CONTINUE READING

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Lysophosphatidic Acid 4270 JOURNAL OF BIOLOGICAL CHEMISTRY VOLUME

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