New mechanistic and therapeutic targets for pediatric heart failure: report from a National Heart, Lung, and Blood Institute working group.

@article{Burns2014NewMA,
  title={New mechanistic and therapeutic targets for pediatric heart failure: report from a National Heart, Lung, and Blood Institute working group.},
  author={Kristin M Burns and Barry J. Byrne and Bruce D Gelb and Bernhard K{\"u}hn and Leslie A Leinwand and Seema Mital and Gail Denise Pearson and Mark D. Rodefeld and Joseph W. Rossano and Brian L Stauffer and Michael D Taylor and Jeffrey Allen Towbin and Andrew N Redington},
  journal={Circulation},
  year={2014},
  volume={130 1},
  pages={
          79-86
        }
}
Pediatric heart failure (HF) is the inability of the heart of an infant, child, or adolescent to meet the body’s metabolic demands. It involves circulatory, neurohumoral, and molecular abnormalities that manifest as edema, respiratory distress, growth failure, and exercise intolerance. The myriad causes include inherited and acquired myocardial anomalies (cardiomyopathy [CM]), volume overload (intracardiac shunts, valvular regurgitation), and the unique hemodynamics predicated by a functional… CONTINUE READING

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