New lupane triterpenoids from Solidago canadensis that inhibit the lyase activity of DNA polymerase beta.

@article{Chaturvedula2004NewLT,
  title={New lupane triterpenoids from Solidago canadensis that inhibit the lyase activity of DNA polymerase beta.},
  author={V. S. Chaturvedula and B. Zhou and Z. Gao and S. Thomas and S. Hecht and D. Kingston},
  journal={Bioorganic & medicinal chemistry},
  year={2004},
  volume={12 23},
  pages={
          6271-5
        }
}
  • V. S. Chaturvedula, B. Zhou, +3 authors D. Kingston
  • Published 2004
  • Chemistry, Medicine
  • Bioorganic & medicinal chemistry
  • Bioassay-directed fractionation of a methyl ethyl ketone extract of Solidago canadensis L. (Asteraceae), using an assay to detect the lyase activity of DNA polymerase beta, resulted in the isolation of the four new lupane triterpenoids 1-4 and the seven known compounds lupeol, lupeyl acetate, ursolic acid, cycloartenol, cycloartenyl palmitate, alpha-amyrin acetate, and stigmasterol. The structures of the new compounds were established as 3beta-(3R-acetoxyhexadecanoyloxy)-lup-20(29)-ene (1… CONTINUE READING
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    References

    SHOWING 1-10 OF 12 REFERENCES
    Four major saponins from Solidago canadensis.
    • 26
    epi-Cubebanes from Solidago canadensis.
    • 25