New lupane triterpenoids from Solidago canadensis that inhibit the lyase activity of DNA polymerase beta.

@article{Chaturvedula2004NewLT,
  title={New lupane triterpenoids from Solidago canadensis that inhibit the lyase activity of DNA polymerase beta.},
  author={Venkata Sai Prakash Chaturvedula and Bing-nan Zhou and Zhijie Gao and Shannon J Thomas and Sidney M Hecht and David G I Kingston},
  journal={Bioorganic & medicinal chemistry},
  year={2004},
  volume={12 23},
  pages={
          6271-5
        }
}
Bioassay-directed fractionation of a methyl ethyl ketone extract of Solidago canadensis L. (Asteraceae), using an assay to detect the lyase activity of DNA polymerase beta, resulted in the isolation of the four new lupane triterpenoids 1-4 and the seven known compounds lupeol, lupeyl acetate, ursolic acid, cycloartenol, cycloartenyl palmitate, alpha-amyrin acetate, and stigmasterol. The structures of the new compounds were established as 3beta-(3R-acetoxyhexadecanoyloxy)-lup-20(29)-ene (1… CONTINUE READING
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