New loci for body fat percentage reveal link between adiposity and cardiometabolic disease risk

  title={New loci for body fat percentage reveal link between adiposity and cardiometabolic
disease risk},
  author={Yingchang Tang Lu and Felix R Day and Stefan Gustafsson and Martin L Buchkovich and Jianbo Na and V{\'e}ronique Bataille and Diana L Cousminer and Zari Dastani and Alexander W. Drong and T{\"o}nu Esko and David M. Evans and Mario Falchi and Mary F Feitosa and Teresa M. Ferreira and {\AA}sa K Hedman and Robin Haring and Pirro G Hysi and Mark M. Iles and Anne E Justice and Stavroula Kanoni and Vasiliki Lagou and Rui Li and Xin Zhiguo Li and Adam E Locke and Chen D. Lu and Reedik M{\"a}gi and John R. B. Perry and Tune H. Pers and Qibin Qi and Marianna Sanna and Ellen M. Schmidt and William R. Scott and Dmitry Shungin and Alexander Teumer and Anna A. E. Vinkhuyzen and Ryan W. Walker and Harm-Jan Westra and MingFeng Zhang and Weihua Zhang and Jing Hua Zhao and Zhihong Zhu and Uzma Afzal and Tarunveer S Ahluwalia and Stephan J L Bakker and Claire Bellis and Am{\'e}lie Bonnefond and Katja M Borodulin and Aron S Buchman and Tommy E Cederholm and Audrey C. Choh and Hyung Jin Choi and Joanne E. Curran and Lisette C. P. G. M. de Groot and Philip L De Jager and Rosalie A. M. Dhonukshe-Rutten and Anke W. Enneman and Elodie Eury and Daniel S Evans and Tom J. Forsen and Nele Friedrich and Fr{\'e}d{\'e}ric Fumeron and Melissa E. Garcia and Simone G{\"a}rtner and Bok-ghee Han and Aki S. Havulinna and Caroline Hayward and Dena G. Hernandez and Hans L. Hillege and Till Ittermann and Jack W. Kent and Ivana Kol{\vc}i{\'c} and Tiina Laatikainen and Jari Lahti and Irene Mateo Leach and Christine G. Lee and Jong-Young Lee and Tian Liu and Youfang Liu and St{\'e}phane Lobbens and Marie Loh and Leo-Pekka Lyytik{\"a}inen and Carolina Medina-Gomez and Karl Micha{\"e}lsson and Mike A. Nalls and Carrie M Nielson and Laticia Oozageer and Laura Pascoe and Lavinia Paternoster and Ozren Pola{\vs}ek and Samuli Ripatti and Mark A. Sarzynski and Chan Soo Shin and Nina Smolej Naran{\vc}i{\'c} and Dominik Spira and Priya Srikanth and Elisabeth Steinhagen-Thiessen and Y. J. Sung and Karin M A Swart and Leena Taittonen and Toshiko Tanaka and Emmi Tikkanen and Nathalie van der Velde and Natasja M. van Schoor and Niek Verweij and Alan F. Wright and Lei Yu and Joseph M. Zmuda and Niina Eklund and Terrence E. Forrester and Niels Grarup and Anne U. Jackson and Kati Kristiansson and Teemu Kuulasmaa and Johanna Kuusisto and Peter Lichtner and Jian'an Luan and Anubha Mahajan and Satu M{\"a}nnist{\"o} and Cameron D. Palmer and Janina S. Ried and Robert Scott and Alena Stan{\vc}{\'a}kov{\'a} and Peter J Wagner and Ayşe Demirkan and Angela D{\"o}ring and Vilmundur Gudnason and Douglas P Kiel and Brigitte Kuehnel and Massimo Mangino and Barbara Mcknight and Cristina Menni and Jeffrey R. O'Connell and Ben A. Oostra and Alan R. Shuldiner and Kijoung Song and Liesbeth Vandenput and Cornelia M van Duijn and Peter Vollenweider and Charles Cody White and Michael Boehnke and Yvonne Boettcher and Richard S. Cooper and Nita G Forouhi and Christian Gieger and Harald Grallert and Aroon D. Hingorani and Torben J\orgensen and Pekka J Jousilahti and Mika Kivimaki and Meena Kumari and Markku Laakso and Claudia Langenberg and Allan Linneberg and Amy Luke and Colin A Mckenzie and Aarno V Palotie and Oluf Pedersen and Annette Peters and Konstantin Strauch and Bamidele O. Tayo and Nicholas J Wareham and David A. Bennett and Lars Bertram and John Blangero and Matthias Bl{\"u}her and Claude Bouchard and Harry Campbell and Nam H Cho and Steve Cummings and Stefan A. Czerwinski and Ilja Demuth and Dr. med. Rahel Eckardt and Johan G Eriksson and Luigi Ferrucci and O. H. Franco and Philippe Froguel and Ronald T. Gansevoort and Torben Hansen and Tamara B. Harris and Nicholas D Hastie and Markku Heli{\"o}vaara and Albert Hofman and Joanne M. Jordan and Antti M. Jula and Mika A. P. K{\"a}h{\"o}nen and Eero O. Kajantie and Paul Knekt and Seppo Koskinen and Peter Kovacs and Terho Lehtim{\"a}ki and Lars Lind and Yongmei Liu and Eric S. Orwoll and Clive Osmond and Markus Perola and Louis P{\'e}russe and Olli T. Raitakari and Tuomo Rankinen and D. Chandrasekhar Rao and Treva K. Rice and Fernando Rivadeneira and Igor Rudan and Veikko V Salomaa and Thorkild I. A. S\orensen and Michael Stumvoll and Anke Toenjes and Bradford Towne and Gregory J Tranah and Angelo Tremblay and Andr{\'e} G. Uitterlinden and Pim van der Harst and Erkki Vartiainen and Jorma S. A. Viikari and Veronique Vitart and Marie Claude Vohl and Henry V{\"o}lzke and Mark Walker and Henri Wallaschofski and Sarah H Wild and James F Wilson and Lo{\"i}c Yengo and D Timothy Bishop and Ingrid B. Borecki and John Campbell Chambers and L. Adrienne Cupples and Abbas Dehghan and Panagiotis Deloukas and Ghazaleh Fatemifar and Caroline Fox and Terrence S. Furey and Lude Franke and Jiali Han and David J. Hunter and Juha M Karjalainen and Fredrik Karpe and Robert C. Kaplan and Jaspal Singh Kooner and Mark I. McCarthy and Joanne M. Murabito and Andrew P. Morris and Julia Bishop and Kari E. North and C Ohlsson and Ken K Ong and Inga Prokopenko and J Brent Richards and Eric E. Schadt and Tim D. Spector and Elisabeth I M Widen and Cristen J. Willer and Jian Yang and Erik Ingelsson and Karen L. Mohlke and Joel Hirschhorn and John Andrew Pospisilik and M C Carola Zillikens and Cecilia M. Lindgren and Tuomas O Kilpel{\"a}inen and Ruth J. F. Loos},
  booktitle={Nature communications},
To increase our understanding of the genetic basis of adiposity and its links to cardiometabolic disease risk, we conducted a genome-wide association meta-analysis of body fat percentage (BF%) in up to 100,716 individuals. Twelve loci reached genome-wide significance (P<5 × 10(-8)), of which eight were previously associated with increased overall adiposity (BMI, BF%) and four (in or near COBLL1/GRB14, IGF2BP1, PLA2G6, CRTC1) were novel associations with BF%. Seven loci showed a larger effect on… CONTINUE READING
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