New loci associated with kidney function and chronic kidney disease

  title={New loci associated with kidney function and chronic kidney disease},
  author={Anna K{\"o}ttgen and Carsten Alexander B{\"o}ger and Christian Fuchsberger and Matthias Olden and Nicole L. Glazer and Afshin Parsa and Xiaoyi Gao and Qiong Yang and Albert Vernon Smith and Jeffrey R. O'Connell and Man Li and Helena X. Schmidt and Toshiko Tanaka and Adrian Isaacs and S. S. Ketkar and Soo Myung Hwang and Andrew D. Johnson and Abbas Dehghan and Alexander Teumer and Guillaume Par{\'e} and Elizabeth J. Atkinson and Tanja Zeller and Kurt Lohman and Marilyn C Cornelis and Nicole Probst-Hensch and Florian Kronenberg and Anke Toenjes and Caroline Hayward and Thor Aspelund and Gudny Eiriksdottir and Lenore J. Launer and T. B. Harris and Evadnie Rampersaud and Braxton D. Mitchell and Dan E Arking and Eric Boerwinkle and Maksim Struchalin and Margherita Cavalieri and Andrew A Singleton and Francesco Giallauria and Jeffrey E. Metter and Ian H. de Boer and Talin Haritunians and Thomas S. Lumley and David S Siscovick and Bruce M. Psaty and Maria Carola Zillikens and BenA. Oostra and Mary F Feitosa and Michael Province and Mariza de Andrade and Stephen T. Turner and Arne Schillert and Andreas Ziegler and Philipp S Wild and Renate B. Schnabel and Sandra Wilde and Thomas Munzel and Tennille Shintana Leak and Thomas Illig and Norman Klopp and Christa Meisinger and H. M. Wichmann and W. K{\"o}nig and Lina Zgaga and Tatijana Zemunik and Ivana Kol{\vc}i{\'c} and Cosetta Minelli and Frank B Hu and {\AA}sa Johansson and Wilmar Igl and Ghazal Zaboli and Sarah H Wild and AlanF. Wright and Harry Campbell and David Ellinghaus and Stefan Schreiber and Yurii S. Aulchenko and Janine F. Felix and Fernando Rivadeneira and Andr{\'e} G. Uitterlinden and Albert Hofman and Medea Imboden and Dorothea Nitsch and Anita Brandstaetter and Barbara Kollerits and Lyudmyla Kedenko and Reedik M{\"a}gi and Michael Stumvoll and Peter Kovacs and Mladen Boban and Susan F. M. Campbell and Karlhans Endlich and Henry V{\"o}lzke and Heyo Klaus Kroemer and Matthias Nauck and Uwe Voelker and Ozren Pola{\vs}ek and Veronique Vitart and Sunita Badola and Alexander N. Parker and Paul M. Ridker and Sharon L. R. Kardia and Stefan S Blankenberg and Yongmei Liu and Gary C. Curhan and Andre Franke and Thierry Rochat and Bernhard Paulweber and Inga Prokopenko and Wei Wang and Vilmundur Gudnason and Alan R. Shuldiner and Josef Coresh and Reinhold Schmidt and Luigi Ferrucci and Michael G. Shlipak and Cornelia M. van Duijn and Ingrid B. Borecki and Bernhard Kraemer and Igor Rudan and Ulf Gyllensten and James F Wilson and Jacqueline C. M. Witteman and Peter P. Pramstaller and R. Bruce Rettig and Nicholas D. Hastie and Daniel Chasman and W. H. Kao and Iris M. Heid and Caroline Fox},
  journal={Nature Genetics},
Chronic kidney disease (CKD) is a significant public health problem, and recent genetic studies have identified common CKD susceptibility variants. The CKDGen consortium performed a meta-analysis of genome-wide association data in 67,093 individuals of European ancestry from 20 predominantly population-based studies in order to identify new susceptibility loci for reduced renal function as estimated by serum creatinine (eGFRcrea), serum cystatin c (eGFRcys) and CKD (eGFRcrea < 60 ml/min/1.73 m2… CONTINUE READING


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Cystinuria. Semin Nephrol 2008;28:181–191

  • A Mattoo, DS Goldfarb
  • 2008

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