New loci associated with central cornea thickness include COL5A1, AKAP13 and AVGR8.

  title={New loci associated with central cornea thickness include COL5A1, AKAP13 and AVGR8.},
  author={Veronique Vitart and Goran Benci{\'c} and Caroline Hayward and Jelena {\vS}kunca Herman and Jennifer M. Huffman and Susan Mary Campbell and Kajo Bu{\'c}an and Pau Navarro and Grgo Gunja{\vc}a and Josipa Marin and Lina Zgaga and Ivana Kol{\vc}i{\'c} and Ozren Pola{\vs}ek and Mirna Kirin and Nicholas D Hastie and James F Wilson and Igor Rudan and Harry Campbell and Z. Vatavuk and Brian Fleck and Alan R Wright},
  journal={Human molecular genetics},
  volume={19 21},
Central corneal thickness (CCT) is a highly heritable trait, which has been proposed to influence disorders of the anterior segment of the eye. A genome-wide association study (GWAS) of CCT was performed in 2269 individuals from three Croatian and one Scottish population. In the discovery set (1445 individuals), two genome-wide significant associations were identified for single nucleotide polymorphisms rs12447690 (β = 0.23 SD, P = 4.4 × 10(-9)) and rs1536482 (β = 0.22 SD, P = 7.1 × 10(-8)) for… CONTINUE READING


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