New loci and coding variants confer risk for age-related macular degeneration in East Asians

@article{Cheng2015NewLA,
  title={New loci and coding variants confer risk for age-related macular degeneration in East Asians},
  author={Ching-Yu Cheng and K. Yamashiro and Li Jia Chen and Jeeyun Ahn and Lulin Huang and Lvzhen Huang and C. Cheung and M. Miyake and P. Cackett and I. Yeo and A. Laude and R. Mathur and J. Pang and K. Sim and A. Koh and Peng Chen and Shu-Yen Lee and Doric Wong and C. M. Chan and B. Loh and Yaoyao Sun and S. D{\'a}vila and I. Nakata and H. Nakanishi and Yumiko Akagi-Kurashige and N. Gotoh and A. Tsujikawa and F. Matsuda and K. Mori and S. Yoneya and Yoichi Sakurada and H. Iijima and T. Iida and S. Honda and T. Lai and P. O. Tam and H. Chen and Shibo Tang and X. Ding and F. Wen and Fang Lu and Xiongze Zhang and Yi Shi and Peiquan Zhao and Bowen Zhao and Jinghong Sang and B. Gong and R. Dorajoo and Jian-Min Yuan and W. Koh and R. V. van Dam and Y. Friedlander and Ying Lin and M. Hibberd and J. Foo and N. Wang and Chang Hua Wong and G. Tan and S. Park and M. Bhargava and L. Gopal and T. Naing and Jiemin Liao and Peng Guan Ong and P. Mitchell and P. Zhou and Xuefeng Xie and Jinlong Liang and J. Mei and Xin Jin and S. Saw and M. Ozaki and T. Mizoguchi and Y. Kurimoto and S. Woo and Hum Chung and H. Yu and J. Shin and D. H. Park and I. T. Kim and Woohyok Chang and M. Sagong and Sang-joon Lee and H. Kim and J. Lee and Y. Li and Jianjun Liu and Y. Teo and C. Heng and T. Lim and Suk-Kyun Yang and K. Song and E. Vithana and T. Aung and J. Bei and Yi-Xin Zeng and E. Tai and Xiao Xin Li and Zhenglin Yang and Kyu-Hyung Park and C. Pang and N. Yoshimura and Tien Yin Wong and C. Khor},
  journal={Nature Communications},
  year={2015},
  volume={6}
}
Age-related macular degeneration (AMD) is a major cause of blindness, but presents differently in Europeans and Asians. Here, we perform a genome-wide and exome-wide association study on 2,119 patients with exudative AMD and 5,691 controls, with independent replication in 4,226 patients and 10,289 controls, all of East Asian descent, as part of The Genetics of AMD in Asians (GAMA) Consortium. We find a strong association between CETP Asp442Gly (rs2303790), an East Asian-specific mutation, and… Expand
Genetic risk factors for late age-related macular degeneration in India
Association of coding and UTR variants in the known regions with wet age-related macular degeneration in Han Chinese population
The Contribution of Genetic Architecture to the 10-Year Incidence of Age-Related Macular Degeneration in the Fellow Eye.
Identification of PGF as a New Gene for Neovascular Age-Related Macular Degeneration in a Chinese Population.
Genetic Association of Age-Related Macular Degeneration and Polypoidal Choroidal Vasculopathy.
  • L. Chen
  • Medicine
  • Asia-Pacific journal of ophthalmology
  • 2020
...
1
2
3
4
5
...

References

SHOWING 1-10 OF 73 REFERENCES
Seven New Loci Associated with Age-Related Macular Degeneration
...
1
2
3
4
5
...