New lidocaine lozenge as topical anesthesia compared to lidocaine viscous oral solution before upper gastrointestinal endoscopy

@article{Mogensen2012NewLL,
  title={New lidocaine lozenge as topical anesthesia compared to lidocaine viscous oral solution before upper gastrointestinal endoscopy},
  author={Stine Hasling Mogensen and Charlotte Treldal and Erik Feldager and Sylvia Pulis and Jette Jacobsen and Ove Andersen and Mette Rasmussen},
  journal={Local and regional anesthesia},
  year={2012},
  volume={5},
  pages={17 - 22}
}
OBJECTIVE To evaluate the effect and acceptance of a new lidocaine lozenge compared with a lidocaine viscous oral solution as a pharyngeal anesthetic before upper gastrointestinal endoscopy (UGE), a diagnostic procedure commonly performed worldwide during which many patients experience severe discomfort mostly because of the gag reflex. [...] Key MethodPARTICIPANTS The single-blinded, randomized, controlled study involved 110 adult patients undergoing diagnostic UGE at the Department of Gastroenterology…Expand
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Simulations showed that the plasma concentrations would be below the toxic limit after repeated dosing every second hour with 25 mg bupivacaine for five days, based on PK simulations of repeated doses of 25 mg every two hours for 16 hr a day, the lozenges can be administered with minimum risk of exceeding the toxiclimit.
Lidocaine spray versus viscous lidocaine solution for pharyngeal local anesthesia in upper gastrointestinal endoscopy: Systematic review and meta‐analysis
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This work aimed to assess the efficacy and safety by meta‐analysis between these two methods for local anesthesia by lidocaine before upper gastrointestinal endoscopy: simple spray and viscous solution.
Anesthesia Innovations for Endoscopy of Gastrointestinal Tract
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The present review focuses on pre-anesthetic assessment, anesthetic drugs used, monitoring practices, and post-anesthesia care for anesthesia innovations in GIE procedures.
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