New lessons about old molecules: how type I interferons shape Th1/Th17-mediated autoimmunity in the CNS.

Abstract

Type I interferons (IFN-alpha and IFN-beta) were discovered more than five decades ago and are widely used for the treatment of human autoimmune diseases such as multiple sclerosis (MS). Despite their highly beneficial features, the precise mechanism of action remains speculative. Given the frequent side effects of IFN-alpha/beta therapy, understanding its… (More)
DOI: 10.1016/j.molmed.2010.06.001

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Cite this paper

@article{Prinz2010NewLA, title={New lessons about old molecules: how type I interferons shape Th1/Th17-mediated autoimmunity in the CNS.}, author={Marco Prinz and Ulrich Kalinke}, journal={Trends in molecular medicine}, year={2010}, volume={16 8}, pages={379-86} }