New lesions detected by single nucleotide polymorphism array-based chromosomal analysis have important clinical impact in acute myeloid leukemia.

@article{Tiu2009NewLD,
  title={New lesions detected by single nucleotide polymorphism array-based chromosomal analysis have important clinical impact in acute myeloid leukemia.},
  author={Ram{\'o}n V. Tiu and Lukasz Pawel Gondek and Christine L O'keefe and Jungwon Huh and Mikkael A. Sekeres and Paul Elson and Michael A. McDevitt and Xiao Fei Wang and Mark J Levis and Judith E. Karp and Anjali S. Advani and Jaroslaw Maciejewski},
  journal={Journal of clinical oncology : official journal of the American Society of Clinical Oncology},
  year={2009},
  volume={27 31},
  pages={5219-26}
}
PURPOSE Cytogenetics is the primary outcome predictor in acute myeloid leukemia (AML). Metaphase cytogenetics (MC) detects an abnormal karyotype in only half of patients with AML, however. Single nucleotide polymorphism arrays (SNP-A) can detect acquired somatic uniparental disomy (UPD) and other cryptic defects, even in samples deemed normal by MC. We hypothesized that SNP-A will improve detection of chromosomal defects in AML and that this would enhance the prognostic value of MC. PATIENTS… CONTINUE READING

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