New isoxazole derivatives of retinoids: synthesis and activity on growth and differentiation of tumor cells.

@article{Simoni1992NewID,
  title={New isoxazole derivatives of retinoids: synthesis and activity on growth and differentiation of tumor cells.},
  author={Daniele Simoni and Stefano Manfredini and Mojgan Aghazadeh Tabrizi and Rita Bazzanini and Pier Giovanni Baraldi and Roberto Ferroni and F Traniello and Claudio Nastruzzi and Giordana Feriotto and Roberto Gambari},
  journal={Drug design and discovery},
  year={1992},
  volume={8 3},
  pages={165-77}
}
The effects of several newly synthesized isoxazole analogues of retinoids on differentiation and proliferation of 'in vitro' cultured tumor cell lines are reported. Some of the tested compounds exhibit significative differentiating action, inducing adipogenic conversion of the Chinese hamster FH06T1-1 cell line in a range of 2-10 times the activity of… CONTINUE READING