New isomeric classes of topically active ocular hypotensive carbonic anhydrase inhibitors: 5-substituted thieno[2,3-b]thiophene-2-sulfonamides and 5-substituted thieno[3,2-b]thiophene-2-sulfonamides.

@article{Prugh1991NewIC,
  title={New isomeric classes of topically active ocular hypotensive carbonic anhydrase inhibitors: 5-substituted thieno[2,3-b]thiophene-2-sulfonamides and 5-substituted thieno[3,2-b]thiophene-2-sulfonamides.},
  author={Jocelyn Prugh and George D. Hartman and Pierre J Mallorga and Brian M. McKeever and Stuart R Michelson and Mark A. Murcko and H Schwam and Ralph L. Smith and J M Sondey and James P. Springer},
  journal={Journal of medicinal chemistry},
  year={1991},
  volume={34 6},
  pages={1805-18}
}
A series of 5-substituted thieno[2,3-b]- and thieno[3,2-b)- and thieno[3,2-b)thiophene-2-sulfonamides was prepared and evaluated for topical ocular hypotensive activity in glaucoma models. The 5-substituents were varied to maximize both inhibitory potency against carbonic anhydrase and water solubility. At the same time, these substituents were varied in… CONTINUE READING