New isoforms of rat Aquaporin-4.

  title={New isoforms of rat Aquaporin-4.},
  author={Svein Erik Moe and Jan Gunnar Sorbo and Rikke Sogaard and Thomas Zeuthen and Ole Petter Ottersen and Torgeir T. Holen},
  volume={91 4},
Aquaporin-4 (AQP4) is a brain aquaporin implicated in the pathophysiology of numerous clinical conditions including brain edema. Here we show that rat AQP4 has six cDNA isoforms, formed by alternative splicing. These are named AQP4a-f, where AQP4a and AQP4c correspond to the two classical M1 and M23 isoforms, respectively. The various isoforms are differentially expressed in kidney and brain, and their prevalence does not correspond to the level of the respective mRNAs, pointing to… CONTINUE READING