New isocysteine building blocks and chemoselective peptide ligation.

Abstract

Boc-, Fmoc- and Cbz-protected isocysteine building blocks were prepared by a concise three-step procedure starting from thiomalic acid. The use of Boc/Trt-protected isocysteine provided convenient access to isocysteinyl peptides that allow the chemoselective ligation of unprotected peptide fragments in water. The pH-dependency of the isocysteine-mediated… (More)

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Cite this paper

@article{Dose2004NewIB, title={New isocysteine building blocks and chemoselective peptide ligation.}, author={Christian Dose and Oliver Seitz}, journal={Organic & biomolecular chemistry}, year={2004}, volume={2 1}, pages={59-65} }