New iridoids from the medicinal plant Barleria prionitis with potent activity against respiratory syncytial virus.

@article{Chen1998NewIF,
  title={New iridoids from the medicinal plant Barleria prionitis with potent activity against respiratory syncytial virus.},
  author={Jian Lu Chen and P. Y. Blanc and Cheryl A Stoddart and Mark Bogan and E J Rozhon and Neil G. Parkinson and Zhi-long Ye and Raymond D. Cooper and Michael J. Balick and Weerachai Nanakorn and Michael R Kernan},
  journal={Journal of natural products},
  year={1998},
  volume={61 10},
  pages={1295-7}
}
Two new iridoid glycosides (1 and 2), together with the known compounds barlerin (3) and verbascoside (4), were isolated from Barleria prionitis. The new iridoid glycosides were determined to be 6-O-trans-p-coumaroyl-8-O-acetylshanzhiside methyl ester (1) and its cis isomer (2) by using spectroscopic, especially 2D NMR, data. A 3:1 mixture of 1 and 2 was shown to have potent in vitro activity against respiratory syncytial virus (EC50 2.46 microgram/mL, IC50 42.2 microgram/mL). 

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