New investigational drugs for androgenetic alopecia

@article{ValenteDuartedeSousa2013NewID,
  title={New investigational drugs for androgenetic alopecia},
  author={Isabel Cristina Valente Duarte de Sousa and Antonella Tosti},
  journal={Expert Opinion on Investigational Drugs},
  year={2013},
  volume={22},
  pages={573 - 589}
}
Introduction: Androgenetic alopecia (AGA) is the most common form of hair loss, however current treatment options are limited and moderately effective. In the past few years, there has been an increased interest in deciphering the molecular mechanisms responsible for this disorder, which has opened the possibility of novel treatments that promise to not only stimulate hair growth, but also to induce formation of new hair follicles. Areas covered: The future holds more effective topical… 
Experimental and early investigational drugs for androgenetic alopecia
TLDR
It is proposed that topically applied medications, or intra-dermal injected or implanted materials, are preferable treatment modalities, minimizing side effect risks as compared to systemically applied treatments.
Conventional and novel stem cell based therapies for androgenic alopecia
TLDR
The therapeutic agents that have been used for androgenic alopecia are analyzed and the potential of new therapies based on advances in stem cell technologies and regenerative medicine are emphasized.
Safety concerns when using novel medications to treat alopecia
TLDR
This review summarizes the safety concerns when using novel therapeutic modalities such as JAK inhibitors, hair transplantation, mesotherapy, oral minoxidil, platelet-rich plasma, microneedling, and 5α-reductase inhibitors for treating hair loss.
Emerging treatments in alopecia
TLDR
This work discusses the use of stem cells, growth factors, cellular pathways and robotic hair transplant, among other emerging therapies used for alopecia, and searches the literature for recently published articles discussing new treatment options as well as mechanisms involved in alopECia.
Hair Restoration in Androgenetic Alopecia: Looking Beyond Minoxidil, Finasteride and Hair Transplantation
TLDR
The relatively newly understood pathophysiological factors behind the genesis of AGA apart from the hormonal factors like the Wnt/β-catenin pathway, follicular micro-inflammation, prostaglandin imbalance, loss of extracellular matrix and oxidative stress are dwell upon.
New Treatments for Hair Loss.
Microneedling for androgenetic alopecia not responding to conventional treatment
TLDR
Five cases of AA treated with microneedling along with conventional treatment showed good growth of hair at the end of 3 months, and the hair growth was maintained till 3 months on last follow-up for majority and one and half years for one of the case.
Treatments options for alopecia
TLDR
This paper aims to provide an overview of available treatments for the most common forms of alopecia in adults (androgenetic alopECia [AGA], alopicia areata and cicatricialAlopecias) after reviewing the literature in PubMed, Google Scholar and ClinicalTrial.gov.
“Cold” X5 Hairlaser™ used to treat male androgenic alopecia and hair growth: an uncontrolled pilot study
TLDR
A positive trend in hair growth was observed due to the chronic use of the novel cold X5 hairlaser device, and this positive benefit while in full agreement with other low laser hair devices requires intensive further investigation.
...
1
2
3
4
...

References

SHOWING 1-10 OF 78 REFERENCES
Promising therapies for treating and/or preventing androgenic alopecia.
TLDR
While there are a number of potential treatment options, good clinical trial data proving hair growth efficacy is limited and new cell mediated treatment approaches may be available for AGA.
Molecular mechanisms of androgenetic alopecia
  • R. Trüeb
  • Biology, Medicine
    Experimental Gerontology
  • 2002
Alopecia secondary to mesotherapy.
Androgen responsive genes as they affect hair growth.
TLDR
Results from this study indicate caspase 3 to be of primary importance in normal hair homeostasis and that DHT may be signaling greater expression of caspases, inducing apoptosis in androgenetic alopecia.
Molecular mechanisms regulating hair follicle development.
  • S. Millar
  • Biology, Medicine
    The Journal of investigative dermatology
  • 2002
TLDR
This review is to summarize recent progress in the understanding of the molecular mechanisms regulating hair follicle formation, and to discuss ways in which this information may eventually be utilized in the clinic.
Hair regrowth following a Wnt- and follistatin containing treatment: safety and efficacy in a first-in-man phase 1 clinical trial.
TLDR
It is demonstrated that a single intradermal administration of HSC improved hair growth in subjects with androgenetic alopecia and is a clinical substantiation of previous preclinical research with Wnts, follistatin, and other growth factors associated with wound healing and regeneration.
Raising hairs
TLDR
New approaches to hair loss treatments seek to apply the latest biological understanding of hair growth and hair follicle cycling, rather than focusing on the androgen signaling underlying the conversion of adult, terminal hair to thin vellus hairs.
Prostaglandin D2 Inhibits Hair Growth and Is Elevated in Bald Scalp of Men with Androgenetic Alopecia
TLDR
PGD2 is defined as an inhibitor of hair growth in AGA and the PGD2-GPR44 pathway is suggested as a potential target for treatment, providing new insight into the pathogenesis of AGA.
Valproic Acid Induces Hair Regeneration in Murine Model and Activates Alkaline Phosphatase Activity in Human Dermal Papilla Cells
TLDR
The findings indicate that small molecules that activate the Wnt/β-catenin pathway, such as VPA, can potentially be developed as drugs to stimulate hair re-growth.
Roxithromycin antagonizes catagen induction in murine and human hair follicles: implication of topical roxithromycin as hair restoration reagent
TLDR
Roxithromycin antagonized the in vitro inhibitory effect of IFN-γ on proliferation of keratinocytes and induction of apoptosis in murine and human hair bulb and is new candidate as a hair restoration drug for AGA.
...
1
2
3
4
5
...