New investigational drugs for androgenetic alopecia

@article{ValenteDuartedeSousa2013NewID,
  title={New investigational drugs for androgenetic alopecia},
  author={Isabel Cristina Valente Duarte de Sousa and Antonella Tosti},
  journal={Expert Opinion on Investigational Drugs},
  year={2013},
  volume={22},
  pages={573 - 589}
}
Introduction: Androgenetic alopecia (AGA) is the most common form of hair loss, however current treatment options are limited and moderately effective. In the past few years, there has been an increased interest in deciphering the molecular mechanisms responsible for this disorder, which has opened the possibility of novel treatments that promise to not only stimulate hair growth, but also to induce formation of new hair follicles. Areas covered: The future holds more effective topical… 
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This work discusses the use of stem cells, growth factors, cellular pathways and robotic hair transplant, among other emerging therapies used for alopecia, and searches the literature for recently published articles discussing new treatment options as well as mechanisms involved in alopECia.
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The relatively newly understood pathophysiological factors behind the genesis of AGA apart from the hormonal factors like the Wnt/β-catenin pathway, follicular micro-inflammation, prostaglandin imbalance, loss of extracellular matrix and oxidative stress are dwell upon.
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Five cases of AA treated with microneedling along with conventional treatment showed good growth of hair at the end of 3 months, and the hair growth was maintained till 3 months on last follow-up for majority and one and half years for one of the case.
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This paper aims to provide an overview of available treatments for the most common forms of alopecia in adults (androgenetic alopECia [AGA], alopicia areata and cicatricialAlopecias) after reviewing the literature in PubMed, Google Scholar and ClinicalTrial.gov.
“Cold” X5 Hairlaser™ used to treat male androgenic alopecia and hair growth: an uncontrolled pilot study
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A positive trend in hair growth was observed due to the chronic use of the novel cold X5 hairlaser device, and this positive benefit while in full agreement with other low laser hair devices requires intensive further investigation.
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