New insights on the role of the endocannabinoid system in the regulation of energy balance

  title={New insights on the role of the endocannabinoid system in the regulation of energy balance},
  author={Blandine Gatta-Cherifi and Daniela Cota},
  journal={International Journal of Obesity},
Within the past 15 years, the endocannabinoid system (ECS) has emerged as a lipid signaling system critically involved in the regulation of energy balance, as it exerts a regulatory control on every aspect related to the search, the intake, the metabolism and the storage of calories. An overactive endocannabinoid cannabinoid type 1 (CB1) receptor signaling promotes the development of obesity, insulin resistance and dyslipidemia, representing a valuable pharmacotherapeutic target for obesity and… 
Hypothalamic endocannabinoids in obesity: an old story with new challenges
How these lipids are dynamically regulated in obesity onset, by diet and metabolic hormones in specific hypothalamic neurons, the impact of gender, and the role of endocannabinoid metabolizing enzymes as promising targets for tackling obesity and related diseases are discussed.
Multiple endocannabinoid-mediated mechanisms in the regulation of energy homeostasis in brain and peripheral tissues
The current data support the notion that eCB signalling is not only engaged in the development but also in the maintenance of obesity, whereby specific cell types in central and peripheral tissues are key sites in regulating the entire body’s energy homeostasis.
The Endocannabinoid System and Physical Activity—A Robust Duo in the Novel Therapeutic Approach against Metabolic Disorders
The aim of this review was to provide the most up-to-date state of knowledge about the interplay between the ECS activity and physical exercises in the novel therapeutic and preventive approach toward metabolic pathologies.
Endocannabinoid System and Its Regulation by Polyunsaturated Fatty Acids and Full Spectrum Hemp Oils
Clinical evidence reviewed in this study links PUFAs and cannabinoids to changes in ECS tone, immune function, metabolic and oxidative stress adaptation, and overall maintenance of a well-balanced systemic function of the body.
Peripheral endocannabinoid signaling controls hyperphagia in western diet-induced obesity
Pharmacological Actions and Potential Therapeutic Use of Cannabinoids in Duchenne’s Muscular Dystrophy
In this chapter, the chemical properties and functional role of the endocannabinoids as well as plant-derived cannabinoids during skeletal muscle formation and repair under physiological conditions aswell as DMD are summarized.
The anti-inflammatory effect of bacterial short chain fatty acids is partially mediated by endocannabinoids
The data show that the anti-inflammatory effects of SCFAs are partly mediated by the EC system suggesting that there may be other pathways involved in the modulation of the immune system via the gut microbiome.
A systematic review of the effects of oleoylethanolamide, a high‐affinity endogenous ligand of PPAR‐α, on the management and prevention of obesity
OEA may be a key component of the physiological system involved in the regulation of dietary fat consumption and energy homeostasis; therefore, it is suggested as a possible therapeutic agent for the management of obesity.


The role of the endocannabinoid system in the neuroendocrine regulation of energy balance
A perspective on new promising strategies to selectively target the ECS in the context of energy balance regulation is given and new evidence suggests that peripherally restricted CB1 antagonists might be efficacious for the treatment of obesity and its associated metabolic disorders.
The emerging role of the endocannabinoid system in endocrine regulation and energy balance.
The ability of the endocannabinoid system to control appetite, food intake, and energy balance has recently received great attention, particularly in the light of the different modes of action underlying these functions.
Activation of the peripheral endocannabinoid system in human obesity.
The findings support the presence of a peripheral endocannabinoid system that is upregulated in human obesity and increased in mature human adipocytes compared with in preadipocytes and was found in several human tissues.
Second generation CB1 receptor blockers and other inhibitors of peripheral endocannabinoid overactivity and the rationale of their use against metabolic disorders
An overview of the roles the ECS plays outside the brain in regulating metabolism is provided, and the latest advances in the development of neutral and/or peripherally restricted CB1 antagonists, and other state of the art strategies that minimize endocannabinoid overactivity are highlighted.
CB1 receptors: emerging evidence for central and peripheral mechanisms that regulate energy balance, metabolism, and cardiovascular health
  • D. Cota
  • Biology, Medicine
    Diabetes/metabolism research and reviews
  • 2007
Drugs targeting the endogenous cannabinoid system (ECS), a neuromodulatory system involved in the regulation of various aspects of energy balance and eating behaviour through central and peripheral mechanisms, may provide a novel, effective approach to the prevention and management of CVD, type 2 diabetes and obesity.