New insights on the role of CXCR4 in cancer metastasis.

  title={New insights on the role of CXCR4 in cancer metastasis.},
  author={Albert Zlotnik},
  journal={The Journal of pathology},
  volume={215 3},
The evolutionarily conserved chemokine superfamily encodes small peptide molecules that bind G-protein-coupled receptors. In humans, this superfamily includes at least 46 ligands and 18 receptors. In general, chemokines and their receptors form a chemotactic network that regulates the migration of cells to specific micro-anatomical destinations within an organism in an organized and non-random manner. Recent studies place chemokine-chemokine receptor pairs at the centre of not only… CONTINUE READING

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