New insights on oxidative stress in cancer.

  title={New insights on oxidative stress in cancer.},
  author={Roberta Visconti and Domenico Luca Grieco},
  journal={Current opinion in drug discovery & development},
  volume={12 2},
Cancer initiation and progression has been linked to oxidative stress, a condition in which the balance between production and disposal of reactive oxygen or nitrogen species is altered. Oxidative stress has several protumorigenic effects, such as increasing DNA mutation rate or inducing DNA damage, genome instability and cell proliferation. Conversely, oxidative stress also exerts antitumorigenic actions, and it is has been linked to senescence and apoptosis, two major mechanisms that… CONTINUE READING

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