New insights into visceral hypersensitivity—clinical implications in IBS

@article{Zhou2011NewII,
  title={New insights into visceral hypersensitivity—clinical implications in IBS},
  author={QiQi Zhou and G. Nicholas Verne},
  journal={Nature Reviews Gastroenterology &Hepatology},
  year={2011},
  volume={8},
  pages={349-355}
}
A subset of patients with IBS have visceral hypersensitivity and/or somatic hypersensitivity. Visceral hypersensitivity might have use as a clinical marker of IBS and could account for symptoms of urgency for bowel movements, bloating and abdominal pain. The mechanisms that lead to chronic visceral hypersensitivity in patients who have IBS are unclear. However, several working models may be considered, including: nociceptive input from the colon that leads to hypersensitivity; increased… CONTINUE READING
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