New insights into the structure and mechanism of iodothyronine deiodinases.

@article{Schweizer2015NewII,
  title={New insights into the structure and mechanism of iodothyronine deiodinases.},
  author={Ulrich Schweizer and Clemens Steegborn},
  journal={Journal of molecular endocrinology},
  year={2015},
  volume={55 3},
  pages={
          R37-52
        }
}
  • Ulrich Schweizer, Clemens Steegborn
  • Published in
    Journal of molecular…
    2015
  • Medicine, Biology
  • Iodothyronine deiodinases are a family of enzymes that remove specific iodine atoms from one of the two aromatic rings in thyroid hormones (THs). They thereby fine-tune local TH concentrations and cellular TH signaling. Deiodinases catalyze a remarkable biochemical reaction, i.e., the reductive elimination of a halogenide from an aromatic ring. In metazoans, deiodinases depend on the rare amino acid selenocysteine. The recent solution of the first experimental structure of a deiodinase… CONTINUE READING

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