New insights into the structure and function of the plasminogen/plasmin system.

@article{Law2013NewII,
  title={New insights into the structure and function of the plasminogen/plasmin system.},
  author={Ruby H P Law and Diana Abu-Ssaydeh and James C. Whisstock},
  journal={Current opinion in structural biology},
  year={2013},
  volume={23 6},
  pages={836-41}
}
Plasminogen is the zymogen form of plasmin, an enzyme that plays a fundamental role in the dissolution of fibrin clots, the extracellular matrix and other key proteins involved in immunity and tissue repair. Comprising seven distinct domains (an N-terminal Pan-apple domain (PAp), 5 kringle domains (KR) and the serine protease domain (SP)), plasminogen undergoes a complex, incompletely understood conformational change that is key to its activation. Here, we review our current understanding of… CONTINUE READING

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