New insights into the role of podocytes in proteinuria

  title={New insights into the role of podocytes in proteinuria},
  author={Jaakko Patrakka and K. Tryggvason},
  journal={Nature Reviews Nephrology},
Disturbances in many different molecular pathways and interactions can lead to the same clinical end points of proteinuria and end-stage renal disease. Proteinuria is often accompanied by a cytopathological change in the glomerulus that is referred to as effacement (retraction) of the podocyte foot processes. The molecular mechanisms that lead to proteinuria and podocyte effacement are poorly understood; therefore, targeted therapies are lacking. During the past 5 years, however, a large body… CONTINUE READING

From This Paper

Figures, tables, and topics from this paper.


Publications citing this paper.
Showing 1-10 of 74 extracted citations


Publications referenced by this paper.
Showing 1-10 of 51 references

Association of genetic variants at 3q22 with nephropathy in patients with type 1 diabetes mellitus

  • B He
  • Am. J. Hum. Genet
  • 2009

enhanced expression of Janus kinase-signal tranducer and activator of transcription pathway members in human diabetic nephropathy

  • Berthier, C C.
  • Diabetes 58,
  • 2009

Similar Papers

Loading similar papers…