New insights into the role of glycogen synthase kinase-3 in Alzheimer's disease.

@article{Medina2014NewII,
  title={New insights into the role of glycogen synthase kinase-3 in Alzheimer's disease.},
  author={Miguel Medina and Jes{\'u}s {\'A}vila},
  journal={Expert opinion on therapeutic targets},
  year={2014},
  volume={18 1},
  pages={69-77}
}
INTRODUCTION Glycogen synthase kinase-3 (GSK-3) is recognized as a crucial player in many cellular functions and its activity is tightly controlled by complex mechanisms that are each dependent upon specific signaling pathways. Furthermore, GSK-3 dysfunction has been linked to a number of pathologies, including Alzheimer's disease (AD). In particular, the involvement of GSK-3 in several key pathophysiological pathways leading to AD and neurodegenerative diseases has placed this enzyme in a… CONTINUE READING

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