New insights into the role of RNase L in innate immunity.

Abstract

The interferon (IFN)-inducible 2'-5'-oligoadenylate synthetase (OAS)/RNase L pathway blocks infections by some types of viruses through cleavage of viral and cellular single-stranded RNA. Viruses induce type I IFNs that initiate signaling to the OAS genes. OAS proteins are pathogen recognition receptors for the viral pathogen-associated molecular pattern… (More)
DOI: 10.1089/jir.2010.0120

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@article{Chakrabarti2011NewII, title={New insights into the role of RNase L in innate immunity.}, author={Arindam Chakrabarti and Babal K Jha and Robert H. Silverman}, journal={Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research}, year={2011}, volume={31 1}, pages={49-57} }