New insights into the role of BubR1 in mitosis and beyond.

  title={New insights into the role of BubR1 in mitosis and beyond.},
  author={Roger E. Karess and Katja Wassmann and Zohra Rahmani},
  journal={International review of cell and molecular biology},
BubR1 is a critical component of the spindle assembly checkpoint, the surveillance mechanism that helps maintain the high fidelity of mitotic chromosome segregation by preventing cells from initiating anaphase if one or more kinetochores are not attached to the spindle. BubR1 also helps promote the establishment of stable kinetochore-microtubule attachments during prometaphase. In this chapter, we review the structure, functions, and regulation of BubR1 in these "classical roles" at the… CONTINUE READING


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