New insights into the regulation of the actin cytoskeleton by tropomyosin.

@article{Wang2010NewII,
  title={New insights into the regulation of the actin cytoskeleton by tropomyosin.},
  author={Chuanhu Wang and Lynne M. Coluccio},
  journal={International review of cell and molecular biology},
  year={2010},
  volume={281},
  pages={
          91-128
        }
}
The actin cytoskeleton is regulated by a variety of actin-binding proteins including those constituting the tropomyosin family. Tropomyosins are coiled-coil dimers that bind along the length of actin filaments. In muscles, tropomyosin regulates the interaction of actin-containing thin filaments with myosin-containing thick filaments to allow contraction. In nonmuscle cells where multiple tropomyosin isoforms are expressed, tropomyosins participate in a number of cellular events involving the… CONTINUE READING

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