New insights into the regulation of Na+,K+-ATPase by ouabain.

@article{Silva2012NewII,
  title={New insights into the regulation of Na+,K+-ATPase by ouabain.},
  author={Elisabete Magalh{\~a}es Silva and Patr{\'i}cio Soares-da-Silva},
  journal={International review of cell and molecular biology},
  year={2012},
  volume={294},
  pages={
          99-132
        }
}
Cardiac glycosides have been widely used in the treatment of congestive heart failure and cardiac arrhythmias. The mechanism of their positive ionotropic effect is well characterized and is based on the inhibition of Na(+),K(+)-ATPase. However, recently it has been discovered that circulating endogenous cardiotonic steroids bind to Na(+),K(+)-ATPase, activate cell signaling pathways, and regulate diverse cellular functions. Thus, they play an important role in both physiological and… CONTINUE READING
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