New insights into the pharmacokinetics of spironolactone.

  title={New insights into the pharmacokinetics of spironolactone.},
  author={H W Overdiek and Walter A. J. J. Hermens and Frans W. H. M. Merkus},
  journal={Clinical pharmacology and therapeutics},
  volume={38 4},
Four healthy men took a single oral dose of 200 mg spironolactone after a standardized breakfast. Blood samples were drawn until 24 hours after dosing. A specific HPLC method was used to determine the serum concentrations of spironolactone and its metabolites 7 alpha-thiomethylspirolactone, 6 beta-hydroxy-7 alpha-thiomethylspirolactone, and canrenone. Pharmacokinetic parameters were derived from the serum concentration-time course of each compound. Spironolactone, 7 alpha-thiomethylspirolactone… CONTINUE READING