New insights into the multidimensional concept of macrophage ontogeny, activation and function

  title={New insights into the multidimensional concept of macrophage ontogeny, activation and function},
  author={Florent Ginhoux and Joachim L. Schultze and Peter J. Murray and Jordi Ochando and Subhra K. Biswas},
  journal={Nature Immunology},
Macrophages have protective roles in immunity to pathogens, tissue development, homeostasis and repair following damage. Maladaptive immunity and inflammation provoke changes in macrophage function that are causative of disease. Despite a historical wealth of knowledge about macrophages, recent advances have revealed unknown aspects of their development and function. Following development, macrophages are activated by diverse signals. Such tissue microenvironmental signals together with… 

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