New insights into the mode of action of anti-inflammatory drugs

@article{Vane1990NewII,
  title={New insights into the mode of action of anti-inflammatory drugs},
  author={John R. Vane and R. M. Botting},
  journal={Inflammation Research},
  year={1990},
  volume={44},
  pages={1-10}
}
The discovery of a second cyclooxygenase has provided fresh impetus to the search for new anti-inflammatory drugs. The second enzyme is effectively absent from healthy tissues but its levels rise dramatically during inflammation. It can be induced in migratory cells by bacterial lipopolysaccharide, cytokines and growth factors. The constitutive cyclooxygenase-1 (COX-1) can thus be considered a “housekeeping” enzyme, in contrast to cyclooxygenase-2 (COX-2) which is activated by tissue damage… CONTINUE READING
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