New insights into the metabolic and nutritional determinants of severe combined immunodeficiency

@inproceedings{Field2015NewII,
  title={New insights into the metabolic and nutritional determinants of severe combined immunodeficiency},
  author={Martha S. Field and Elena Kamynina and David Watkins and David S. Rosenblatt and Patrick J Stover},
  booktitle={Rare diseases},
  year={2015}
}
Human mutations in MTHFD1 have recently been identified in patients with severe combined immunodeficiency (SCID). SCID results from inborn errors of metabolism that cause impaired T- and B-cell proliferation and function. One of the most common causes of SCID is adenosine deaminase (ADA) deficiency, which ultimately inhibits DNA synthesis and cell division… CONTINUE READING