New insights into the mechanism of Wnt signaling pathway activation.

  title={New insights into the mechanism of Wnt signaling pathway activation.},
  author={Akira Kikuchi and Hideki Yamamoto and Akira Sato and Shinji Matsumoto},
  journal={International review of cell and molecular biology},
Wnts compromise a large family of secreted, hydrophobic glycoproteins that control a variety of developmental and adult processes in all metazoan organisms. Recent advances in the Wnt-signal studies have revealed that distinct Wnts activate multiple intracellular cascades that regulate cellular proliferation, differentiation, migration, and polarity. Although the mechanism by which Wnts regulate different pathways selectively remains to be clarified, evidence has accumulated that in addition to… CONTINUE READING


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2011.Vangl2 promotesWnt/planar cell polarity-like signaling by antagonizing Dvl1-mediated feedback inhibition in growth cone guidance

  • B Shafer
  • Dev. Cell
  • 2011

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