New insights into the inhibition of human neutrophil elastase by heparin.

@article{Spencer2006NewII,
  title={New insights into the inhibition of human neutrophil elastase by heparin.},
  author={Jean L. Spencer and Phillip J. Stone and Matthew A. Nugent},
  journal={Biochemistry},
  year={2006},
  volume={45 30},
  pages={9104-20}
}
In the normal feedback mechanism of injury and repair in the lung, fragmented heparan sulfate proteoglycans (HSPGs) from damaged extracellular matrix and cells are believed to interact with elastases to limit their activity. An imbalance in the HSPG-elastase response may play an important role in situations where uncontrolled lung injury leads to diseases such as emphysema. To gain insight into this complex process of heparin and heparan sulfate regulation of elastases, an experimental study… CONTINUE READING