New insights into the enigma of immunoglobulin D.

  title={New insights into the enigma of immunoglobulin D.},
  author={Kang Chen and Andrea Cerutti},
  journal={Immunological reviews},
  volume={237 1},
Immunoglobulin D (IgD) has remained a mysterious antibody class for almost half a century. IgD was initially thought to be a recently evolved Ig isotype expressed only by some mammalian species, but recent discoveries in fishes and amphibians demonstrate that IgD was present in the ancestor of all jawed vertebrates and has important immunological functions. The structure of IgD has been very dynamic throughout evolution. Mammals can express IgD through alternative splicing and class switch… CONTINUE READING