New insights into the central PACAPergic system from the phenotypes in PACAP- and PACAP receptor-knockout mice.

@article{Hashimoto2006NewII,
  title={New insights into the central PACAPergic system from the phenotypes in PACAP- and PACAP receptor-knockout mice.},
  author={Hitoshi Hashimoto and Norihito Shintani and Akemichi Baba},
  journal={Annals of the New York Academy of Sciences},
  year={2006},
  volume={1070},
  pages={
          75-89
        }
}
Pituitary adenylate cyclase-activating polypeptide (PACAP) is a structurally highly conserved neuropeptide and displays pleiotropic activity, including functioning as a neurotransmitter, neuromodulator, and neurotrophic factor. A series of recent experiments, including genetic manipulation of PACAP and its receptors, has led to better understanding of both normal and pathological processes in which PACAP has been proposed to play a role, and sheds light on previously uncharacterized functions… CONTINUE READING

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